Thursday, February 28, 2013

FDA halts Amgen study after teen patient death

(AP) ? Federal health regulators have halted Amgen's studies of its drug Sensipar after the death of a 14-year-old patient in a company trial.

The Food and Drug Administration said Tuesday it is still gathering information about the death, but has shut down all studies of the drug in children.

Sensipar is approved in adults to treat over-activity of the parathyroid gland, which can lead to brittle bones, kidney stones and abdominal pain. It has been used since 2004 to treat symptoms of chronic kidney disease and parathyroid cancer.

Amgen Inc. had been studying the drug to see whether it works in children.

The Thousand Oaks, Calif.-based company said in a statement that it "is working as rapidly as possible to understand the circumstances of what happened."

The FDA said on its website that it is unclear whether Amgen's drug had a role in the patient's death, but it is reminding doctors to prescribe it carefully.

The drug is known to lower calcium levels, sometimes to a dangerous extent.

The agency says doctors should monitor patients' calcium levels monthly to make sure they don't fall to dangerous levels. Signs of a calcium deficiency include muscle cramping, convulsions and burning or prickling sensations.

The most common side effects of the drug in adults include nausea, vomiting and diarrhea.

Amgen reported annual sales of $800 million for Sensipar in 2011, its most recent full-year financial report.

Company shares fell 7 cents to $89.48 in afternoon trading Tuesday.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-02-26-US-Amgen-Drug-Trial-Death/id-8243bad9f67440a7afb974cd2adb30bb

shaun white carolina panthers amanda bynes Revolution TV Show bankofamerica revolution rosh hashanah

NASCAR Fans to Sue for Damages from Nationwide Crash

Source: http://www.thehollywoodgossip.com/2013/02/nascar-fans-to-sue-for-damages-from-nationwide-crash/

the temptations rush limbaugh sandra fluke green book some like it hot duke university whale shark whale shark

Wednesday, February 27, 2013

Weary of crises, Americans tune out budget cut talk

WASHINGTON (AP) ? President Barack Obama is pulling out all the stops to warn just what could happen if automatic budget cuts kick in. Americans are reacting with a collective yawn.

They know the shtick: Obama raises the alarm, Democrats and Republicans accuse each other of holding a deal hostage, there's a lot of yelling on cable news, and then finally, when everyone has made their points, a deal is struck and the day is saved.

Maybe not this time. Two days before $85 billion in cuts are set to hit federal programs with all the precision of a wrecking ball, there are no signs that the White House and Republicans in Congress are even negotiating. Both sides appear quietly resigned to the prospect that this is one bullet we just may not dodge.

Still, for all the grim predictions, Americans seem to be flipping the channel to something a little less, well, boring. They wonder, haven't we been here before?

It's like deja vu, says Patrick Naylon, who runs an audiovisual firm in San Francisco: "The same stuff, over and over again."

Texas native Corby Biddle, 53, isn't losing sleep over the cuts. No way the government will let vital services collapse, he said as he visited tourist attractions this week in downtown Atlanta.

"It will get resolved. They will kick the can down the road," Biddle said.

Usually, that's exactly what happens. Even the cuts behind the current panic were originally supposed to kick in on Jan. 1 ? part of the fiscal-cliff combo of spending cuts and tax hikes that economists warned could nudge the nation back into recession. For all the high drama, lawmakers finally acted on New Year's Day, compromising on taxes and punting the spending cuts to March 1.

And the blunt instrument known as the "sequester" that's set to deliver the cuts? That too was the progeny of another moment of government-by-brinksmanship, a concession that in 2011 made possible the grand bargain that saved the U.S. from a first-ever default on its debt.

Even if the current cuts go through, the impact won't be immediate. Federal workers would be notified next week that they will have to take up to a day every week off without pay, but the furloughs won't start for a month due to notification requirements. That will give negotiators some breathing room to keep working on a deal.

But you can only cry wolf so many times before people just stop paying attention.

"I know you guys must get tired of it," Obama told a crowd in Virginia on Tuesday. "Didn't we just solve this thing? Now we've got another thing coming up?"

Three out of 4 Americans say they aren't following the spending cuts issue very closely, according to a Pew Research Center poll released this week. It's a significant drop from the nearly 4 in 10 who in December said they were closely following the fiscal-cliff debate.

Public data from Google's search engine shows that at its peak in December, the search term "fiscal cliff" was about 10 times as popular as "sequestration" has been in recent days. Even "debt ceiling," not a huge thriller for the web-surfing crowd, maxed out in July 2011 at about three times the searches the sequester is now getting.

"We're now approaching the next alleged deadline of doom. And voters, having been told previously that the world might end, found it did not in the past and are becoming more skeptical that it will in the future," said Peter Brown of the nonpartisan Quinnipiac University Polling Institute.

And let's face it: When it comes to policy issues that can really put an audience to sleep, "sequestration" is right up there with filibuster reform, chained CPI and carried interest.

For all the angst about layoffs, furloughs and slashes to government contracts, the markets don't seem to be rattled, either. The Dow Jones Industrial Average, after falling below 13,000 at the height of the fiscal cliff debacle, has been buoyant ever since, spending the last month hovering just below 14,000.

"I shrug my shoulders because I don't believe any of those severe cuts will go through," said Karen Jensen, a retired hospital administrator who stopped to talk in New York's Times Square. "Life goes on as it has before."

But if the Obama administration hasn't managed to convince Americans these spending cuts could be the real deal, it's not for lack of trying.

Each day the cuts grow nearer sees a new dire warning from the White House about another government function that will take a hit if they go into effect ? what White House chief of staff Denis McDonough has called a "devastating list of horribles." Homeland Security Secretary Janet Napolitano warned Monday that her agency will be forced to furlough 5,000 border patrol agents. Education Secretary Arne Duncan has said 70,000 preschool kids could be removed from Head Start. Fewer air traffic controllers could mean 90-minute delays or longer in major cities, and visiting hours at all 398 national parks are likely to be cut, the administration has said.

The White House has circulated 51 reports ? one for each state, plus the District of Columbia ? localizing the effects of the cuts. On Tuesday, Obama took his cautionary tale to a shipbuilding site in Newport News, Va., calling attention to how the cuts could impede the military. The White House says in Virginia alone, about 90,000 civilians working for the Defense Department would be furloughed, for a nearly $650 million reduction in gross pay.

"The president needs to stop campaigning, stop trying to scare the American people, stop trying to scare the states," Republican Gov. Bobby Jindal of Louisiana said Monday after governors from both parties met with Obama behind closed doors. "Now's the time to cut spending. It can be done without jeopardizing the economy. It can be done without jeopardizing critical services."

The age-old Republican desire for a scaled-back federal government makes it clear why, on the one hand, the GOP isn't scrambling to avert the cuts ? especially when Obama insists on more tax revenues in any deal to turn them off. On the other hand, Obama is banking on polls that show if the cuts go through, Republicans are likely to bear most of the blame.

Both parties agree that if you're going to cut spending, an indiscriminate mechanism like the sequester is the wrong way to do it. After all, the whole point of the endeavor was to set in motion ramifications so unbearable that lawmakers would be forced to come together and hash out a better plan before the deadline.

Count James Ford of Louisville, Ky., among those still holding out hope.

"They'll come up with something to keep the thing going," he said. "They always do."

___

Associated Press writers Jeff Martin in Atlanta, Jake Pearson in New York and Dylan Lovan in Louisville, Ky., contributed to this report.

___

Reach Josh Lederman on Twitter at http://twitter.com/joshledermanAP

Source: http://news.yahoo.com/wary-crises-americans-tune-budget-cut-talk-080137738--finance.html

direct tv wimbledon ray allen Savages Home Run Derby 2012 San Diego fireworks steve nash

Cell discovery could hold key to causes of inherited diseases

Feb. 26, 2013 ? Fresh insights into the protective seal that surrounds the DNA of our cells could help develop treatments for inherited muscle, brain, bone and skin disorders.

Researchers have discovered that the proteins within this coating -- known as the nuclear envelope -- vary greatly between cells in different organs of the body.

This variation means that certain disease causing proteins will interact with the proteins in the protective seal to cause illness in some organs, but not others.

Until now scientists had thought that all proteins within the nuclear envelope were the same in every type of organ.

In particular the finding may provide insights into a rare muscle disease, Emery-Dreifuss muscular dystrophy.

This condition causes muscle wastage and heart problems, affects only muscles, even though it is caused by a defect in a nuclear envelope protein found in every cell in the body.

Scientists say that the envelope proteins they have identified as being specific to muscle may interact with the defective nuclear envelope protein that causes Emery-Dreifuss muscular dystrophy, to give rise to the disease.

In a similar way, this may help to explain other heritable diseases that only affect certain parts of the body despite the defective proteins being present in every cell. The study also identified nuclear envelope proteins specific to liver and blood.

Some of these also interact with proteins in all cells that are responsible for other nuclear envelope diseases, ranging from brain and fat to skin diseases, and so may help explain why things go wrong.

Dr Eric Schirmer, of the University of Edinburgh's Wellcome Trust Centre for Cell Biology, who led the study, said: "Nobody could have imagined what we found. The fact that most proteins in the nuclear envelope would be specific for certain tissue types is a very exciting development. This may finally enable us to understand this ever-growing spectrum of inherited diseases as well as new aspects of tissue-specific gene regulation."

The findings build on previous research that showed proteins in the nuclear envelope are linked to more than 20 heritable diseases.

The study, which was supported by the Wellcome Trust and conducted in collaboration with the Stowers Institute for Medical Research, is published in the journal Nucleus.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by University of Edinburgh, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Nadia Korfali, Gavin S. Wilkie, Selene K. Swanson, Vlastimil Srsen, Jose de las Heras, Dzmitry G. Batrakou, Poonam Malik, Nikolaj Zuleger, Alastair R.W. Kerr, Laurence Florens, Eric C. Schirmer. The nuclear envelope proteome differs notably between tissues. Nucleus, 2012; 3 (6): 24 DOI: 10.4161/nucl.22257

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/r8kNvxe1h04/130226113830.htm

derrick rose injury st louis news utah jazz lawrence of arabia denver nuggets correspondents dinner i am legend

Britain's top Catholic cleric resigns, won't elect new pope

LONDON (Reuters) - Britain's most senior Roman Catholic cleric resigned on Monday following allegations he behaved in an inappropriate way with priests, and said he would not take part in the election of Pope Benedict's replacement.

Cardinal Keith O'Brien said he had tendered his resignation some months ago, ahead of his 75th birthday in March and because he was suffering from "indifferent health".

The Vatican said the pope, who steps down on Thursday, had accepted O'Brien's resignation as archbishop of St. Andrews and Edinburgh.

O'Brien, an outspoken opponent of gay marriage, has been reported to the Vatican over allegations of inappropriate behavior stretching back 30 years, according to Britain's Observer newspaper.

The cardinal, who last week advocated allowing Catholic priests to marry as many found it difficult to cope with celibacy, rejected the allegations and was seeking legal advice, his spokesman said.1

"Looking back over my years of ministry: For any good I have been able to do, I thank God. For any failures, I apologize to all whom I have offended," O'Brien said in a statement, which made no reference to the recent allegations.

He said he would not attend the election next month of a new pope, saying: "I do not wish media attention in Rome to be focused on me - but rather on Pope Benedict XVI and on his successor."

The Observer, which gave little detail on the claims, said three priests and a former priest, from a Scottish diocese, had complained over incidents dating back to 1980.

One said the cardinal formed an "inappropriate relationship" with him while another complained of unwanted behavior by O'Brien after a late-night drinking session.

Last year, O'Brien's comments labeling gay marriage a "grotesque subversion" landed him with a "Bigot of the Year" award from British gay rights group Stonewall.

(Reporting by Guy Faulconbridge and Michael Holden; editing by Maria Golovnina and Jon Boyle)

Source: http://news.yahoo.com/britains-most-senior-roman-catholic-cleric-resigns-112040627.html

erin andrews tour de france Magic Mike Anderson Cooper Gay NBA draft 2012 alicia sacramone Don Grady

Skeptical Syrian opposition to attend Rome talks

BERLIN (AP) ? Skeptical Syrian opposition leaders agreed Monday to attend an international conference in Rome after first threatening to boycott the session that was to be the centerpiece of Secretary of State John Kerry's his first overseas mission in his new job.

Opposition leaders had protested what they see as inaction by other nations in the face of violence from Syrian President Bashar Assad's regime.

Kerry not only made a public plea at a joint news conference Monday with British Foreign Secretary William Hague, he also called Moaz Khatib, leader of the Syrian Opposition Council, "to encourage him to come to Rome," a senior U.S. official said. The official, who spoke on condition of anonymity because he wasn't authorized to speak publicly on the matter, described the conversation as "good" but declined to offer more detail.

Spokesman Walid al-Bunni said the council had decided to send a delegation to Rome after all.

Al-Bunni told Al-Arabiya TV the decision was made based on guarantees al-Khatib heard from western diplomats that the conference would be different and that the opposition would receive real commitments this time. "We will go and we will see if the promises are different this time," he said.

After speaking with Khatib, Kerry flew to Berlin from London, the first stop of his first trip as secretary of state ? a hectic nine-country dash through Europe and the Middle East.

Kerry had also dispatched his top Syrian envoy to Cairo in hopes of convincing opposition leaders that their participation is critical to addressing questions from potential donors and securing additional aid from the United States and Europe.

"We are determined that the Syrian opposition is not going to be dangling in the wind, wondering where the support is, if it is coming," Kerry told reporters in London after meeting British Prime Minister David Cameron and Hague. "We are not going to let the Syrian opposition not have its ability to have its voice properly heard in this process."

For his part, Hague said the violence in Syria, especially recent scud missile attacks on the city of Aleppo, was unacceptable and that the west's current position could not be sustained while an "appalling injustice" is being done to Syrian citizens.

"In the face of such murder and threat of instability, our policy cannot stay static as the weeks go by," Hague told reporters, standing beside Kerry. "We must significantly increase support for the Syrian opposition. We are preparing to do just that."

Kerry agreed.

"We are not coming to Rome simply to talk, we are coming to Rome to talk about next steps," Kerry said, adding that he was sympathetic to opposition complaints that they were not getting the support they need to defend themselves against the Assad regime or oust him from power.

"I am very sensitive to that frustration," recalling that as a U.S. senator he was one of several who pushed the administration to consider military aid to the Syrian opposition.

"But I am the new secretary of state ... and the president of the United States has sent me here and sent me to this series of meetings and in Rome because he is concerned about the course of events.

"This moment is ripe for us to be considering what more we can do," he said, adding that if the opposition wants results, "join us" in Rome.

Meanwhile, Syrian Foreign Minister Walid al-Moallem said Monday the Assad regime was ready to hold talks with opposition leaders, the first time that a high-ranking Syrian official has stated publicly that the government would meet with the opposition. Al-Moallem made his comments after meeting in Moscow with Russian officials.

In Washington, State Department spokesman Patrick Ventrell said Moallem's remarks appeared positive but expressed caution about the seriousness of the offer.

"I don't know their motivations, other than to say they continue to rain down horrific attacks on their own people," Ventrell told reporters. "So that speaks pretty loudly and clearly."

If the Assad regime is serious, he said, it should inform the U.N. peace envoy, Lakhdar Brahimi of its readiness for talks. Ventrell said the Assad regime hasn't yet done that.

Obama administration officials have debated whether the U.S. should arm the rebels, with Defense Secretary Leon Panetta and Joint Chiefs of Staff Chairman Gen. Martin Dempsey having said they urged such a course of action. The White House has been unwilling to do so for fears the weapons could end up in the wrong hands. Currently, the U.S. provides only non-lethal support and humanitarian aid.

The United Nations says at least 70,000 people have been killed in Syria's 2-year civil war, which began as an uprising against Assad's regime.

Kerry said the Syrian people "deserve better" than the violence currently gripping their country as he stood alongside Britain's Foreign Secretary William Hague.

___

Associated Press writers Cassandra Vinograd in London and Bradley Klapper in Washington contributed to this report.

Source: http://news.yahoo.com/skeptical-syrian-opposition-attend-rome-talks-204353433.html

aurora borealis gcb mary j blige dionne warwick patricia heaton arsenic and old lace leslie

Triple H takes to Twitter and Tout to blast Brock Lesnar after bloody brawl

Triple H is taking social media by storm with his actions inside and outside the ring.

After sending shockwaves throughout the WWE Universe with his brutal beatdown on Brock Lesnar, The Game delivered his first tweet from his official Twitter account, then promptly taunted Brock with a bold message sent via Tout.

"The ass-kicker is back," an intense Triple H proclaimed in the Tout. "Now the question is: Are you just gonna stand around and bleed? Or are you gonna do something about it?"

The King of Kings seems hell-bent on picking his familiar rival apart both physically and mentally after Lesnar stalked a recovering Mr. McMahon during the WWE Chairman's fight with Paul Heyman to kick off Raw. Lesnar required 18 staples to close the wound on his head suffered in a vicious attack at the hands of the furious Cerebral Assassin.

Now, Triple H has put the heat on Brock through his initial ventures into Twitter and Tout. Does The Game have any other verbal barbs planned for Lesnar in the aftermath of their staggering brawl? And what will The Anomaly say ? or do ? to settle the score as The Road to WrestleMania heats up?

By the looks of it, these two warriors are only getting started.

View Comments

Source: http://www.wwe.com/shows/raw/2013-02-25/triple-h-twitter-tout-blasts-brock-lesnar-after-brawl

Brothers Grimm Tate Stevens Miss Universe 2012 x factor x factor john kerry eastbay